Profiling of PDR1 and MSH2 in Candida glabrata Bloodstream Isolates from a Multicenter Study in China-Reference-Cited by-同舟云学术

Profiling of PDR1 and MSH2 in Candida glabrata Bloodstream Isolates from a Multicenter Study in China

Published:2018-06 Issue:6 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hou Xin¹²³,Xiao Meng¹³,Wang He¹³,Yu Shu-Ying¹²³,Zhang Ge¹³,Zhao Yanan⁴,Xu Ying-Chun¹²³

Affiliation:

1. Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

2. Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China

3. Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases (BZ0447), Beijing, China

4. Public Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers, Newark, New Jersey, USA

Abstract

ABSTRACT Among 158 Candida glabrata bloodstream isolates collected from numerous centers in China, a resistance to fluconazole was seen in 8.9%. Three isolates (1.9%) were resistant to all echinocandins. Multilocus sequence typing (MLST) revealed that sequence type 7 ([ST7] 65.8%) was the most common type, followed by ST3 (7.6%). PDR1 polymorphisms were associated with the acquisition of fluconazole resistance in C. glabrata isolates, while MSH2 polymorphisms were associated with the STs and microsatellite genotypes, irrespective of fluconazole resistance.

Funder

CAMS Innovation Fund for Medical Sciences

National Key Research and Development Program of China

Beijing Innovation Base Cultivation and Development Special Fund

China Scholarship Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00153-18

Reference33 articles.