Revised Interpretation of the Hain Lifescience GenoType MTBC To Differentiate Mycobacterium canettii and Members of the Mycobacterium tuberculosis Complex-Reference-Cited by-同舟云学术

Revised Interpretation of the Hain Lifescience GenoType MTBC To Differentiate Mycobacterium canettii and Members of the Mycobacterium tuberculosis Complex

Published:2019-06 Issue:6 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Loiseau Chloé¹²,Brites Daniela¹²,Moser Irmgard³,Coll Francesc⁴,Pourcel Christine⁵,Robbe-Austerman Suelee⁶,Escuyer Vincent⁷,Musser Kimberlee A.⁷,Peacock Sharon J.⁸,Feuerriegel Silke⁹¹⁰,Kohl Thomas A.⁹¹⁰,Niemann Stefan⁹¹⁰,Gagneux Sebastien¹²,Köser Claudio U.¹¹^ORCID

Affiliation:

1. Swiss Tropical and Public Health Institute, Basel, Switzerland

2. University of Basel, Basel, Switzerland

3. Friedrich-Loeffler-Institut, Federal Institute for Animal Health, Institute of Molecular Pathogenesis, Jena, Germany

4. Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

5. Institute for Integrative Biology of the Cell, Université Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France

6. National Veterinary Services Laboratories, United States Department of Agriculture, Ames, Iowa, USA

7. Wadsworth Center, New York State Department of Health, Albany, New York, USA

8. Department of Medicine, University of Cambridge, Cambridge, United Kingdom

9. Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany

10. German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Germany

11. Department of Genetics, University of Cambridge, Cambridge, United Kingdom

Abstract

Using 894 phylogenetically diverse genomes of the Mycobacterium tuberculosis complex (MTBC), we simulated in silico the ability of the Hain Lifescience GenoType MTBC assay to differentiate the causative agents of tuberculosis. Here, we propose a revised interpretation of this assay to reflect its strengths (e.g., it can distinguish some strains of Mycobacterium canettii and variants of Mycobacterium bovis that are not intrinsically resistant to pyrazinamide) and limitations (e.g., Mycobacterium orygis cannot be differentiated from Mycobacterium africanum ).

Funder

Wellcome Trust

Swiss National Science Foundation

EC | European Research Council

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00159-19

Reference28 articles.

1. Evaluation of Genotype MTBC Assay for Differentiation of Clinical Mycobacterium tuberculosis Complex Isolates

2. Clinical and Laboratory Standards Institute. Laboratory detection and identification of mycobacteria, 2nd edition. CLSI document M48. Clinical and Laboratory Standards Institute, Wayne, PA.

3. Ecology and evolution of Mycobacterium tuberculosis

4. Importance of the Genetic Diversity within the Mycobacterium tuberculosis Complex for the Development of Novel Antibiotics and Diagnostic Tests of Drug Resistance

5. Hain Lifescience GmbH. 2017. GenoType MTBC VER 1.X. Instructions for use IFU-301-11. Hain Lifescience GmbH Nehren Germany.

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