Modified E2 Glycoprotein of Hepatitis C Virus Enhances Proinflammatory Cytokines and Protective Immune Response-Reference-Cited by-同舟云学术

Modified E2 Glycoprotein of Hepatitis C Virus Enhances Proinflammatory Cytokines and Protective Immune Response

Published:2022-06-22 Issue:12 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Vijayamahantesh Vijayamahantesh¹,Patra Tapas¹^ORCID,Meyer Keith¹^ORCID,Alameh Mohamad-Gabriel²,Reagan Erin K.²^ORCID,Weissman Drew²,Ray Ranjit¹³^ORCID

Affiliation:

1. Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, USA

2. Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

3. Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, USA

Abstract

Hepatitis C virus (HCV) E2-CD81 binding dampens protective immune response. We have identified that an alteration of amino acids in the front layer of soluble E2 (sE2) disrupts CD81 interaction and alters the cytokine response.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00523-22

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