Epstein-Barr Virus Entry Utilizing HLA-DP or HLA-DQ as a Coreceptor-Reference-Cited by-同舟云学术

Epstein-Barr Virus Entry Utilizing HLA-DP or HLA-DQ as a Coreceptor

Published:2000-03 Issue:5 Volume:74 Page:2451-2454
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Haan Keith M.¹,Kwok William W.²,Longnecker Richard¹,Speck Peter¹

Affiliation:

1. Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois 60611,1 and

2. Virginia Mason Research Center, Seattle, Washington 981012

Abstract

ABSTRACT Epstein-Barr virus (EBV) glycoprotein gp350/gp220 association with cellular CD21 facilitates virion attachment to B lymphocytes. Membrane fusion requires the additional interaction between virion gp42 and cellular HLA-DR. This binding is thought to catalyze membrane fusion through a further association with the gp85-gp25 (gH-gL) complex. Cell lines expressing CD21 but lacking expression of HLA class II molecules are resistant to infection by a recombinant EBV expressing enhanced green fluorescent protein. Surface expression of HLA-DR, HLA-DP, or HLA-DQ confers susceptibility to EBV infection on resistant cells that express CD21. Therefore, HLA-DP or HLA-DQ can substitute for HLA-DR and serve as a coreceptor in EBV entry.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.5.2451-2454.2000

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