The c- myc Locus Is a Common Integration Site in Type B Retrovirus-Induced T-Cell Lymphomas-Reference-Cited by-同舟云学术

The c- myc Locus Is a Common Integration Site in Type B Retrovirus-Induced T-Cell Lymphomas

Published:2000-03 Issue:5 Volume:74 Page:2466-2471
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Rajan Lakshmi¹,Broussard Dana¹,Lozano Mary¹,Lee Chun G.²,Kozak Christine A.²,Dudley Jaquelin P.¹

Affiliation:

1. Section of Molecular Genetics and Microbiology and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78705,1 and

2. National Institute of Allergy and Infectious Diseases-LMM, National Institutes of Health, Bethesda, Maryland 208922

Abstract

ABSTRACT Type B leukemogenic virus (TBLV) induces rapidly appearing T-cell leukemias. TBLV insertions near the c- myc gene were detectable in 2 of 30 tumors tested, whereas 80% of the tumors showed c- myc overexpression. TBLV insertions on chromosome 15 (including a newly identified locus, Pad7 ) may cause c- myc overexpression by cis -acting effects at a distance.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.5.2466-2471.2000

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