Altered Ribosomes in Antibiotic-Resistant Mutants of Mycobacterium smegmatis-Reference-Cited by-同舟云学术

Altered Ribosomes in Antibiotic-Resistant Mutants of Mycobacterium smegmatis

Published:1976-05 Issue:5 Volume:9 Page:817-823
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Yamada Takeshi¹²,Masuda Kunitsugu¹²,Mizuguchi Yasuo¹²,Suga Kiyoko¹²

Affiliation:

1. Research Institute for Microbial Diseases, Osaka University, Yamada-kami, Suita City, Osaka 565

2. Department of Tuberculosis, National Institute of Health, Shinagawa-ku, Tokyo 141, Japan

Abstract

Two alleles for viomycin-capreomycin resistance ( vic ) in Mycobacterium smegmatis affect ribosome structures. One ( vicA ) affects a component of 50 S subunits and the other ( vicB ) affects a component of 30 S subunits. The locus for neomycin-kanamycin resistance ( nek ), which is linked to vicA and vicB , affects a component of 30 S subunits. Although the erythromycin resistance locus ( ery ) is linked to vic and nek , no ribosomal alterations could be detected. Mutations at the streptomycin locus ( str ) not linked to vic and nek caused alterations of 30 S subunits.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.9.5.817

Reference35 articles.

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