Identification of New Natural CphA Metallo-β-Lactamases CphA4 and CphA5 in Aeromonas veronii and Aeromonas hydrophila Isolates from Municipal Sewage in Central Italy-Reference-Cited by-同舟云学术

Identification of New Natural CphA Metallo-β-Lactamases CphA4 and CphA5 in Aeromonas veronii and Aeromonas hydrophila Isolates from Municipal Sewage in Central Italy

Published:2015-05-18 Issue:8 Volume:59 Page:4990-4993
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob. Agents Chemother.

Author:

Bottoni Carlo,Marcoccia Francesca,Compagnoni Chiara,Colapietro Martina,Sabatini Alessia,Celenza Giuseppe,Segatore Bernardetta,Maturo Maria Giovanna,Amicosante Gianfranco,Perilli Mariagrazia

Abstract

ABSTRACTTwo new natural CphA metallo-β-lactamases, the CphA4 and CphA5 enzymes, were identified in water samples from municipal sewage in central Italy. Compared to CphA, the CphA4 and CphA5 enzymes showed numerous point mutations. These enzymes have a narrow spectrum of substrates focused on carbapenems only. CphA5 showedkcatvalues about 40-, 12-, and 97-fold higher than those observed for CphA4 versus imipenem, ertapenem, and biapenem, respectively.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference11 articles.

1. Aeromonas spp. clinical microbiology and disease;J Infect,2011

2. Phylogenetic diversity, antibiotic resistance and virulence traits of Aeromonas spp. from untreated waters from human consumption;Int J Food Microbiol,2013

3. Aeromonas hydrophila and Aeromonas veronii predominate among potentially pathogenic ciprofloxacin- and tetracycline-resistant Aeromonas isolates from Lake Erie;Appl Environ Microbiol,2014

4. The Aeromonas metallo-β-lactamases: genetics, enzymology, and contribution to drug resistance;Microb Drug Resist,1996

5. First occurrence of an IMP metallo-β-lactamase in Aeromonas cavie: IMP-19 in an isolate from France;Antimicrob Agents Chemother,2007

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