Affiliation:
1. Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom
Abstract
ABSTRACT
The oxidation of morphine by whole-cell suspensions and cell extracts of
Cylindrocarpon didymum
gave rise to the formation of 2,2′-bimorphine. The identity of 2,2′-bimorphine was confirmed by mass spectrometry and
1
H nuclear magnetic resonance spectroscopy.
C. didymum
also displayed activity with the morphine analogs hydromorphone, 6-acetylmorphine, and dihydromorphine, but not codeine or diamorphine, suggesting that a phenolic group at C-3 is essential for activity.
Publisher
American Society for Microbiology
Subject
Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology
Cited by
11 articles.
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