Quinupristin-Dalfopristin Resistance in Streptococcus pneumoniae : Novel L22 Ribosomal Protein Mutation in Two Clinical Isolates from the SENTRY Antimicrobial Surveillance Program-Reference-Cited by-同舟云学术

Quinupristin-Dalfopristin Resistance in Streptococcus pneumoniae : Novel L22 Ribosomal Protein Mutation in Two Clinical Isolates from the SENTRY Antimicrobial Surveillance Program

Published:2003-08 Issue:8 Volume:47 Page:2696-2698
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Jones Ronald N.¹,Farrell David J.²,Morrissey Ian²

Affiliation:

1. The JONES Group/JMI Laboratories, North Liberty, Iowa

2. GR Micro, Ltd., London, United Kingdom

Abstract

ABSTRACT Resistance to quinupristin-dalfopristin (Q/D) among gram-positive cocci has been very uncommon. Two clinical isolates among 8,837 (0.02%) Streptococcus pneumoniae isolates were discovered in 2001 to 2002 with Q/D MICs of 4 μg/ml. Each had a 5-amino-acid tandem duplication (RTAHI) in the L22 ribosomal protein gene ( rplV ) preventing synergistic ribosomal binding of the streptogramin combination. Similar gene duplication has been reported in Q/D-resistant Staphylococcus aureus .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.8.2696-2698.2003

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