Larger Dose Reductions of Vancomycin Required in Neonates with Patent Ductus Arteriosus Receiving Indomethacin versus Ibuprofen-Reference-Cited by-同舟云学术

Larger Dose Reductions of Vancomycin Required in Neonates with Patent Ductus Arteriosus Receiving Indomethacin versus Ibuprofen

Published:2019-08 Issue:8 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cristea S.¹,Allegaert K.²³,Falcao A. C.⁴,Falcao F.⁵⁶,Silva R.⁵,Smits A.³⁷,Knibbe C. A. J.¹⁸,Krekels E. H. J.¹

Affiliation:

1. Division of Biomedicine and Systems Pharmacology, Leiden University, Leiden, The Netherlands

2. Department of Pediatrics, Division of Neonatology, Erasmus MC—Sophia Children’s Hospital, Rotterdam, The Netherlands

3. Department of Development and Regeneration, KU Leuven, Leuven, Belgium

4. Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal

5. Pharmacy Department, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal

6. Department of Pharmacy Practice, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal

7. Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium

8. Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands

Abstract

Ibuprofen and indomethacin are commonly used to induce ductus arteriosus closure in preterm neonates. Our group previously reported that ibuprofen decreased vancomycin clearance by 16%. In this study, we quantified the impact of indomethacin coadministration on vancomycin clearance by extending our vancomycin population pharmacokinetic model with a data set containing vancomycin concentrations measured in preterm neonates comedicated with indomethacin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00853-19

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