Nucleoside Analogue Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase

Author:

Deval Jérôme1,Götte Matthias2

Affiliation:

1. Roche Palo Alto; 3431 Hillview Avenue Palo Alto CA 94304

2. Department of Microbiology & Immunology; McGill University; Montreal Quebec Canada

Publisher

ASM Press

Reference105 articles.

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2. Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase;Arion;Biochemistry,1998

3. Interaction of retroviral reverse transcriptase with template-primer duplexes during replication;Arts;Prog. Nucleic Acid Res. Mol. Biol.,1998

4. Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds;Balzarini;J. Biol. Chem.,1989

5. Defining a molecular mechanism of synergy between nucleoside and nonnucleoside AIDS drugs;Basavapathruni;J. Biol. Chem.,2004

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