Colistin Resistance Caused by Inactivation of the MgrB Regulator Is Not Associated with Decreased Virulence of Sequence Type 258 KPC Carbapenemase-Producing Klebsiella pneumoniae-Reference-Cited by-同舟云学术

Colistin Resistance Caused by Inactivation of the MgrB Regulator Is Not Associated with Decreased Virulence of Sequence Type 258 KPC Carbapenemase-Producing Klebsiella pneumoniae

Published:2016-04 Issue:4 Volume:60 Page:2509-2512
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Arena Fabio¹,Henrici De Angelis Lucia¹,Cannatelli Antonio¹,Di Pilato Vincenzo²,Amorese Marina¹,D'Andrea Marco Maria¹,Giani Tommaso¹,Rossolini Gian Maria¹³⁴⁵

Affiliation:

1. Department of Medical Biotechnologies, University of Siena, Siena, Italy

2. Department of Surgery and Translational Medicine, University of Florence, Florence, Italy

3. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

4. Clinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy

5. Don Carlo Gnocchi Foundation, Florence, Italy

Abstract

ABSTRACT Using a Galleria mellonella animal model, we compared the virulence of two sequence type 258 (ST258) KPC-producing Klebsiella pneumoniae strains, which were representative of the two clades of this clonal lineage, with that of isogenic colistin-resistant mgrB mutants. With both strains, the mgrB mutants did not exhibit modification in virulence. In the G. mellonella model, the clade 1 strain (capsular type cps-1 [ wzi29 , producing KPC-2]) was significantly more virulent than the clade 2 strain (capsular type cps-2 [ wzi154 , producing KPC-3]).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02981-15

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