Vigorous but Short-Term Gamma Interferon T-Cell Responses against a Dominant HLA-A*02-Restricted Measles Virus Epitope in Patients with Measles-Reference-Cited by-同舟云学术

Vigorous but Short-Term Gamma Interferon T-Cell Responses against a Dominant HLA-A*02-Restricted Measles Virus Epitope in Patients with Measles

Published:2003-04-15 Issue:8 Volume:77 Page:5014-5016
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Jaye Assan¹,Herberts Carla A.²,Jallow Sabelle¹,Atabani Sowsan¹,Klein Michel R.¹,Hoogerhout Peter²,Kidd Michael¹,van Els Cécile A. C. M.²,Whittle Hilton C.¹

Affiliation:

1. Medical Research Council Laboratories (MRC), Banjul, The Gambia

2. Laboratory of Vaccine Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands

Abstract

ABSTRACT The absolute and relative abundance of major histocompatibility complex class I-presented viral epitopes is important in the induction and maintenance of antiviral cytotoxic-T-lymphocyte (CTL) responses. We demonstrate that the supra-abundant HLA-A*0201-restricted peptide KLWESPQEI of the measles virus nonstructural C protein induces strong gamma interferon CD8 + -T-cell responses in children with acute measles. However, longitudinal analysis indicates that these responses are only short-lived. Thus, some viral epitopes that can be immunodominant during primary infection may fail to establish memory CTL responses.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.77.8.5014-5016.2003

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