A Novel Antiviral Intervention Results in More Accurate Assessment of Human Immunodeficiency Virus Type 1 Replication Dynamics and T-Cell Decay In Vivo-Reference-Cited by-同舟云学术

A Novel Antiviral Intervention Results in More Accurate Assessment of Human Immunodeficiency Virus Type 1 Replication Dynamics and T-Cell Decay In Vivo

Published:2003-04-15 Issue:8 Volume:77 Page:5037-5038
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Markowitz Martin¹,Louie Michael¹,Hurley Arlene¹,Sun Eugene²,Di Mascio Michele³,Perelson Alan S.³,Ho David D.¹

Affiliation:

1. Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York

2. Abbott Laboratories, Abbott Park, Illinois

3. Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico

Abstract

ABSTRACT Mathematical models provide an understanding of in vivo replication kinetics of human immunodeficiency virus type 1 (HIV-1). With a novel intervention designed for increased potency, we have more accurately deduced the half-lives of virus-producing CD4 + T cells, 0.7 day, and the generation time of HIV-1 in vivo, approximately 2 days, confirming the dynamic nature of HIV-1 replication.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.77.8.5037-5038.2003

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