Characterization of the First OXA-10 Natural Variant with Increased Carbapenemase Activity-Reference-Cited by-同舟云学术

Characterization of the First OXA-10 Natural Variant with Increased Carbapenemase Activity

Published:2019-01 Issue:1 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kotsakis Stathis D.¹²,Flach Carl-Fredrik¹²,Razavi Mohammad¹²,Larsson D. G. Joakim¹²

Affiliation:

1. Department of Infectious Diseases, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

2. Centre for Antibiotic Resistance Research (CARe) at University of Gothenburg, Gothenburg, Sweden

Abstract

While carbapenem resistance in Gram-negative bacteria is mainly due to the production of efficient carbapenemases, β-lactamases with a narrower spectrum may also contribute to resistance when combined with additional mechanisms. OXA-10-type class D β-lactamases, previously shown to be weak carbapenemases, could represent such a case.

Funder

Swedish Research Council VR

Swedish Research Council Formas

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01817-18

Reference85 articles.

1. OXA-type carbapenemases in Acinetobacter baumannii in South America

2. OXA-48-like carbapenemases: the phantom menace