Affiliation:
1. Department of Veterinary Pathobiology and the Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri, USA
Abstract
Pneumonic plague, caused by the Gram-negative bacteria
Yersinia pestis
, is an invasive, rapidly progressing disease with poor survival rates. Following inhalation of
Y. pestis
, bacterial invasion of the lungs and a tissue-damaging inflammatory response allows vascular spread of the infection. Consequently, primary pneumonic plague is a multiorgan disease involving sepsis and necrosis of immune tissues and the liver, as well as bronchopneumonia and rampant bacterial growth.
Funder
HHS | NIH | National Institute of Allergy and Infectious Diseases
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
5 articles.
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