Affiliation:
1. Department of Respiratory Medicine, the Third Affiliated Hospital of Sun Yatsen University of Medical Sciences, 510630 Guangzhou, People's Republic of China
Abstract
ABSTRACT
Of 115 methicillin-resistant
Staphylococcus
strains collected from sputum specimens, 34 strains reduced susceptibility to vancomycin, 9 of which emerged as heterogeneous vancomycin-resistant strains (hetero-VRS), with various degrees of vancomycin resistance at a frequency of 10
−6
or higher. Seventy-six percent (19 of 25) of non-hetero-VRS and 100% (9 of 9) of hetero-VRS were susceptible to synergistic treatment with vancomycin and imipenem. Clinical clearance between 9 hetero-VRS and 25 non-hetero-VRS had an obvious statistical significance (
P
= 0.001). The hetero-VRS may play an important role in vancomycin therapy failure.
Publisher
American Society for Microbiology
Cited by
10 articles.
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