The Bis(Indolyl)Imidazole Alkaloid Nortopsentin A Exhibits Antiplasmodial Activity-Reference-Cited by-同舟云学术

The Bis(Indolyl)Imidazole Alkaloid Nortopsentin A Exhibits Antiplasmodial Activity

Published:2013-05 Issue:5 Volume:57 Page:2362-2364
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Alvarado Stephenie¹,Roberts Bracken F.¹,Wright Amy E.²,Chakrabarti Debopam¹

Affiliation:

1. Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA

2. Harbor Branch Oceanographic Institute at Florida Atlantic University, Fort Pierce, Florida, USA

Abstract

ABSTRACT A library of enriched marine natural product fractions was screened for their antiplasmodial activity using a SYBR green I fluorescence-based assay. Fractions derived from a sponge of the genus Spongosorites exhibited potent inhibition of Plasmodium falciparum growth. This genus of sponge has been reported to contain the nortopsentin and topsentin class of bis-indole imidazole alkaloids. This is the first report of nortopsentin A inhibiting parasite growth at the trophozoite stage at submicromolar 50% inhibitory concentrations (IC 50 ).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02091-12

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