Correlation of In Vitro Susceptibility Based on MICs and Squalene Epoxidase Mutations with Clinical Response to Terbinafine in Patients with Tinea Corporis/Cruris

Author:

Khurana Ananta1ORCID,Masih Aradhana2,Chowdhary Anuradha2ORCID,Sardana Kabir1,Borker Sagar3,Gupta Aastha1,Gautam R. K.1,Sharma P. K.1,Jain Dhruv4

Affiliation:

1. Department of Dermatology, Dr Ram Manohar Lohia Hospital and Postgraduate Institute of Medical Education and Research, New Delhi, India

2. Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India

3. Department of Community Medicine, Dr Ram Manohar Lohia Hospital and Postgraduate Institute of Medical Education and Research, New Delhi, India

4. People’s College of Medical Sciences and Research Centre, Bhopal, Madhya Pradesh, India

Abstract

Recalcitrant dermatophytoses are on the rise in India. High MICs of terbinafine (TRB) and squalene epoxidase ( SQLE ) gene mutations conferring resistance in Trichophyton spp.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference41 articles.

1. Terbinafine

2. Hay RJ, Ashbee HR. 2016. Fungal infections, p 32.1–32.96. In Griffiths CEM, Barker J, Bleiker T, Chalmers R, Creamer D (ed), Rooks textbook of dermatology, 9th ed. Wiley-Blackwell, Oxford, United Kingdom.

3. One-week therapy with oral terbinafine in cases of tinea cruris/corporis

4. Emergence of recalcitrant dermatophytosis in India

5. Dermatophytosis: Fighting the challenge: Conference proceedings and learning points. September 2-3, 2017, PGIMER, Chandigarh, India

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