Affiliation:
1. MedImmune, Gaithersburg, Maryland, USA
Abstract
Alpha toxin (AT) is a cytolytic pore-forming toxin that plays a key role in
Staphylococcus aureus
pathogenesis; consequently, extensive research was undertaken to understand the AT mechanism of action and its utility as a target for novel prophylaxis and treatment strategies against
S. aureus
infections. MEDI4893 (suvratoxumab) is a human anti-AT IgG1 monoclonal antibody (MAb) that targets AT and is currently in phase 2 clinical development.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
20 articles.
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