Affiliation:
1. Institute of General Microbiology, University of Bern, CH-3012 Bern, Switzerland
Abstract
ABSTRACT
Methionine added to minimal medium overcomes the repressing effects of ammonium and cyclic AMP (cAMP) on sexual development and efficiently induces mating and sporulation in homothallic strains of
Schizosaccharomyces pombe
. In heterothallic strains it induces G
1
arrest when cells enter stationary phase. We show that methionine reduces the intracellular cAMP pool and induces the expression of at least two cAMP-repressible genes, including
fbp1
and
ste11
. The easiest interpretation of the results is that methionine induces sexual development via a cAMP-dependent
ste11
signalling pathway.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
15 articles.
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