Construction and Characterization of a Helicobacter pylori clpB Mutant and Role of the Gene in the Stress Response-Reference-Cited by-同舟云学术

Construction and Characterization of a Helicobacter pylori clpB Mutant and Role of the Gene in the Stress Response

Published:1998-01-15 Issue:2 Volume:180 Page:426-429
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Allan Elaine¹,Mullany Peter¹,Tabaqchali Soad¹

Affiliation:

1. Department of Medical Microbiology, St. Bartholomew’s and the Royal London School of Medicine and Dentistry, West Smithfield, London, EC1A 7BE, United Kingdom

Abstract

ABSTRACT Antiserum raised against whole Helicobacter pylori cells identified a novel 94-kDa antigen. The nucleotide sequence of the gene encoding the 94-kDa antigen was determined, and analysis of the deduced amino acid sequence revealed structural features typical of the ClpB ATPase family of stress response proteins. An isogenic H. pylori clpB mutant showed increased sensitivity to high-temperature stress, indicating that the clpB gene product functions as a stress response protein in H. pylori.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.180.2.426-429.1998

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