Trade-Offs between Antibacterial Resistance and Fitness Cost in the Production of Metallo-β-Lactamases by Enteric Bacteria Manifest as Sporadic Emergence of Carbapenem Resistance in a Clinical Setting-Reference-Cited by-同舟云学术

Trade-Offs between Antibacterial Resistance and Fitness Cost in the Production of Metallo-β-Lactamases by Enteric Bacteria Manifest as Sporadic Emergence of Carbapenem Resistance in a Clinical Setting

Published:2021-07-16 Issue:8 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cheung Ching Hei Phoebe¹,Alorabi Mohammed¹²,Hamilton Fergus³,Takebayashi Yuiko¹,Mounsey Oliver¹,Heesom Kate J.⁴,Williams Philip B.⁵,Williams O. Martin⁵,Albur Mahableshwar³,MacGowan Alasdair P.³,Avison Matthew B.¹^ORCID

Affiliation:

1. School of Cellular & Molecular Medicine, University of Bristol, Bristol, United Kingdom

2. Department of Biotechnology, Faculty of Sciences, Taif University, Taif, Kingdom of Saudi Arabia

3. Department of Microbiology, Infection Sciences, Southmead Hospital, North Bristol NHS Trust, Bristol, United Kingdom

4. Bristol Proteomics Facility, University of Bristol, Bristol, United Kingdom

5. Bristol Royal Infirmary, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom

Abstract

Meropenem is a clinically important antibacterial reserved for treatment of multiresistant infections. In meropenem-resistant bacteria of the family Enterobacterales , New Delhi metallo-β-lactamase 1 (NDM-1) is considerably more common than IMP-1, despite both metallo-β-lactamases (MBLs) hydrolyzing meropenem with almost identical kinetics.

Funder

UKRI | Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02412-20

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