The Glycosylphosphatidylinositol Transamidase Complex Subunit PbGPI16 of Plasmodium berghei Is Important for Inducing Experimental Cerebral Malaria-Reference-Cited by-同舟云学术

The Glycosylphosphatidylinositol Transamidase Complex Subunit PbGPI16 of Plasmodium berghei Is Important for Inducing Experimental Cerebral Malaria

Published:2018-08 Issue:8 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Liu Qingyang¹,Zhao Yan¹,Zheng Li¹,Zhu Xiaotong¹,Cui Liwang¹²^ORCID,Cao Yaming¹

Affiliation:

1. Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China

2. Department of Entomology, Pennsylvania State University, University Park, Pennsylvania, USA

Abstract

In animal models of experimental cerebral malaria (ECM), the glycosylphosphatidylinositols (GPIs) and GPI anchors are the major factors that induce nuclear factor kappa B (NF-κB) activation and proinflammatory responses, which contribute to malaria pathogenesis. GPIs and GPI anchors are transported to the cell surface via a process called GPI transamidation, which involves the GPI transamidase (GPI-T) complex.

Funder

The National Institutes of Health

The National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00929-17

Reference62 articles.

1. WHO. 2017. World malaria report 2017. WHO, Geneva, Switzerland.

2. Expression of negative immune regulatory molecules, pro-inflammatory chemokine and cytokines in immunopathology of ECM developing mice