Activation of the Chemokine Receptor CCR1 and Preferential Recruitment of Gαi Suppress RSV Replication: Implications for Developing Novel Respiratory Syncytial Virus Treatment Strategies-Reference-Cited by-同舟云学术

Activation of the Chemokine Receptor CCR1 and Preferential Recruitment of Gαi Suppress RSV Replication: Implications for Developing Novel Respiratory Syncytial Virus Treatment Strategies

Published:2022-11-23 Issue:22 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Li Jiao¹²,Xue Ling¹,Wang Jiachao¹,Meng Aihong³,Qiao Jiajun¹,Li Miao¹,Wang Xiuli¹²,Meng Lingtong¹,Ning Jingyuan¹,Gao Xue¹,Li Wenjian¹,Ma Cuiqing¹,Wei Lin¹^ORCID

Affiliation:

1. Department of Immunology, Key Laboratory of Immune Mechanism and Intervention on Serious Disease in Hebei Province, Hebei Medical University, Shijiazhuang, China

2. Clinical Laboratory, Hebei Key Laboratory of Laboratory Medicine, the Second Hospital of Hebei Medical University, Shijiazhuang, China

3. Respiratory Medicine, the Second Hospital of Hebei Medical University, Shijiazhuang, China

Abstract

Our results revealed a novel mechanism by which RSV escapes innate immunity. That is, although it induces high CCL5 expression, RSV might attenuate the binding of CCL5 by downregulating the expression of CCR1 in respiratory epithelial cells to weaken the inhibitory effect of CCR1 on HSP90 activity and thereby facilitate RSV replication in nonimmune cells.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hebei Province

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01309-22

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