Structures of Foot-and-Mouth Disease Virus with Bovine Neutralizing Antibodies Reveal the Determinant of Intraserotype Cross-Neutralization-Reference-Cited by-同舟云学术

Structures of Foot-and-Mouth Disease Virus with Bovine Neutralizing Antibodies Reveal the Determinant of Intraserotype Cross-Neutralization

Published:2021-11-23 Issue:24 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

He Yong¹²³^ORCID,Li Kun²,Wang Li²,Sun Zixian⁴,Cao Yimei²,Li Pinghua²,Sun Pu²,Bao Huifang²,Zhou Shasha²,Wang Sheng²,Bai Xingwen²,Liu Xuerong⁵,Zhao Lixia⁶,Fan Xiuli⁶,Liu Zaixin²,Lu Zengjun²,Yang Cheng¹,Lou Zhiyong³

Affiliation:

1. Drug Discovery Center for Infectious Disease, College of Pharmacy, Nankai University, Tianjin, China

2. State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Diseases Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

3. MOE Key Laboratory of Protein Science, School of Medicine, Tsinghua University, Beijing, China

4. School of Life Sciences, Tsinghua University, Beijing, China

5. China Agricultural Vet Biology and Technology Co. Ltd., Lanzhou, China

6. The Spirit Jinyu Biological Pharmaceutical Co. Ltd., Hohhot, China

Abstract

Foot-and-mouth disease virus (FMDV) causes a highly contagious and economically devastating disease in cloven-hoofed animals, and neutralizing antibodies play critical roles in the defense against viral infections. Here, we isolated a bovine antibody (R55) using the single B cell antibody isolation technique.

Funder

National Program on Key Research Project of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01308-21

Reference45 articles.

1. Foot-and-Mouth Disease

2. Recombination Patterns in Aphthoviruses Mirror Those Found in Other Picornaviruses