Structures of Foot-and-Mouth Disease Virus with Bovine Neutralizing Antibodies Reveal the Determinant of Intraserotype Cross-Neutralization

Author:

He Yong123ORCID,Li Kun2,Wang Li2,Sun Zixian4,Cao Yimei2,Li Pinghua2,Sun Pu2,Bao Huifang2,Zhou Shasha2,Wang Sheng2,Bai Xingwen2,Liu Xuerong5,Zhao Lixia6,Fan Xiuli6,Liu Zaixin2,Lu Zengjun2,Yang Cheng1,Lou Zhiyong3

Affiliation:

1. Drug Discovery Center for Infectious Disease, College of Pharmacy, Nankai University, Tianjin, China

2. State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Diseases Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

3. MOE Key Laboratory of Protein Science, School of Medicine, Tsinghua University, Beijing, China

4. School of Life Sciences, Tsinghua University, Beijing, China

5. China Agricultural Vet Biology and Technology Co. Ltd., Lanzhou, China

6. The Spirit Jinyu Biological Pharmaceutical Co. Ltd., Hohhot, China

Abstract

Foot-and-mouth disease virus (FMDV) causes a highly contagious and economically devastating disease in cloven-hoofed animals, and neutralizing antibodies play critical roles in the defense against viral infections. Here, we isolated a bovine antibody (R55) using the single B cell antibody isolation technique.

Funder

National Program on Key Research Project of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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