A Role of Epithelial Cells and Virulence Factors in Biofilm Formation by Streptococcus pyogenes In Vitro-Reference-Cited by-同舟云学术

A Role of Epithelial Cells and Virulence Factors in Biofilm Formation by Streptococcus pyogenes In Vitro

Published:2020-09-18 Issue:10 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Alamiri Feiruz¹,Chao Yashuan¹²,Baumgarten Maria³,Riesbeck Kristian⁴,Hakansson Anders P.¹^ORCID

Affiliation:

1. Division of Experimental Infection Medicine, Department of Translational Medicine, Lund University, Malmö, Sweden

2. Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden

3. Division of Infection Medicine, Department of Clinical Sciences, IQ Biotechnology Platform, Lund University, Lund, Sweden

4. Clinical Microbiology, Department of Translational Medicine, Lund University, Malmö, Sweden

Abstract

Biofilm formation by Streptococcus pyogenes (group A streptococcus [GAS]) in model systems mimicking the respiratory tract is poorly documented. Most studies have been conducted on abiotic surfaces, which poorly represent human tissues. We have previously shown that GAS forms mature and antibiotic-resistant biofilms on physiologically relevant epithelial cells. However, the roles of the substratum, extracellular matrix (ECM) components, and GAS virulence factors in biofilm formation and structure are unclear.

Funder

Vetenskapsrådet

Kungliga Fysiografiska Sällskapet i Lund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00133-20

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