Masters of Misdirection: Peptidoglycan Glycosidases in Bacterial Growth

Author:

Weaver Anna1ORCID,Taguchi Atsushi2ORCID,Dörr Tobias345ORCID

Affiliation:

1. Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA

2. SANKEN (The Institute of Scientific and Industrial Research), Osaka University, Ibaraki, Osaka, Japan

3. Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York, USA

4. Department of Microbiology, Cornell University, Ithaca, New York, USA

5. Cornell Institute of Host-Microbe Interactions and Disease, Cornell University, Ithaca, New York, USA

Abstract

The dynamic composition of the peptidoglycan cell wall has been the subject of intense research for decades, yet how bacteria coordinate the synthesis of new peptidoglycan with the turnover and remodeling of existing peptidoglycan remains elusive. Diversity and redundancy within peptidoglycan synthases and peptidoglycan autolysins, enzymes that degrade peptidoglycan, have often made it challenging to assign physiological roles to individual enzymes and determine how those activities are regulated.

Funder

HHS | National Institutes of Health

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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