Affiliation:
1. Department of Bacteriology, Juntendo University, Tokyo, Japan
Abstract
ABSTRACT
We tested the combined activity of vancomycin and seven β-lactam antibiotics against
Staphylococcus aureus
clinical strain Mu3, which displays heterogeneous resistance to vancomycin. When combined with vancomycin, four of the seven tested β-lactams exhibited an additive effect at or near their MICs, while all showed an antagonistic effect at lower, sub-MIC levels. This study implicated the unpredictable nature of combination therapy of β-lactams and vancomycin against
S. aureus
with reduced susceptibility to vancomycin.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
32 articles.
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