Expression of Pseudomonas aeruginosa Antibiotic Resistance Genes Varies Greatly during Infections in Cystic Fibrosis Patients-Reference-Cited by-同舟云学术

Expression of Pseudomonas aeruginosa Antibiotic Resistance Genes Varies Greatly during Infections in Cystic Fibrosis Patients

Published:2018-11 Issue:11 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Martin Lois W.¹,Robson Cynthia L.¹,Watts Annabelle M.¹,Gray Andrew R.²,Wainwright Claire E.³⁴,Bell Scott C.⁴⁵⁶^ORCID,Ramsay Kay A.¹⁴⁵,Kidd Timothy J.⁵,Reid David W.⁵⁶,Brockway Ben⁷,Lamont Iain L.¹^ORCID

Affiliation:

1. Department of Biochemistry, University of Otago, Dunedin, New Zealand

2. Biostatistics Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand

3. Lady Cilento Children's Hospital, Brisbane, Australia

4. Faculty of Medicine, The University of Queensland, Brisbane, Australia

5. QIMR Berghofer Medical Research Institute, Brisbane, Australia

6. Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia

7. Department of Medicine, University of Otago, Dunedin, New Zealand

Abstract

The lungs of individuals with cystic fibrosis (CF) become chronically infected with Pseudomonas aeruginosa that is difficult to eradicate by antibiotic treatment. Two key P. aeruginosa antibiotic resistance mechanisms are the AmpC β-lactamase that degrades β-lactam antibiotics and MexXYOprM, a three-protein efflux pump that expels aminoglycoside antibiotics from the bacterial cells.

Funder

Cystic Fibrosis New Zealand

HS and JC Anderson Trust

New Zealand Health Research Council

Lottery Health Research

Cure Kids

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01789-18