New Ventilated Isolation Cage

Author:

Cook Reginald O.1

Affiliation:

1. National Environmental Health Sciences Center, Research Triangle Park, North Carolina 27709

Abstract

A multifunction lid has been developed for a commercially available transparent animal cage which permits feeding, watering, viewing, long-term holding, and local transport of laboratory rodents on experiment while isolating the surrounding environment. The cage is airtight except for its inlet and exhaust high-efficiency particulate air filters, and it is completely steam-sterilizable. Opening of the cage's feed and water ports causes an inrush of high velocity air which prevents back-migration of aerosols and permits feeding and watering while eliminating need for chemical vapor decontamination. Ventilation system design permits the holding in adjacent cages of animals infected with different organisms without danger of cross-contamination; leaves the animal room odor-free; reduces required bedding changes to twice a month or less, and provides investigators with capability to control precisely individual cage ventilation rates. Forty-eight cages can be conveniently placed on a standard NIH “shoebox” cage rack (60 inches wide × 28 inches deep × 74 inches high) fitted with a simple manifold exhaust system. The entire system is mobile, requiring only an electrical power outlet. Principal application of the caging system is in the area of preventing exposure of animal caretakers to pathogenic substances associated with the animal host, and in reducing handling of animals and their exposure to extraneous contamination.

Publisher

American Society for Microbiology

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference22 articles.

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3. Decker H. M. B. S. Buchanan M. S. Hall and B. S. Goddard. 1962. Air filtration of microbial particles. Public Health Serv. Publ. #953.

4. Gremillion G. G. 1959. The use of bacteria-tight cabinets in the infectious disease laboratory. Proc. Symp. Gnotobiotic Technology 2nd p. 171-182. Univ. of Notre Dame Press Notre Dame Ind.

5. Penetration of submicron TI bacteriophage aerosols and bacterial aerosols through commercial air filters;Harstad J. B.;Proc. Ann. Technical Meeting and Exhibit, 6th, p.,1967

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