Efficacy and Safety of Oral Fosfomycin for Asymptomatic Bacteriuria in Kidney Transplant Recipients: Results from a Spanish Multicenter Cohort-Reference-Cited by-同舟云学术

Efficacy and Safety of Oral Fosfomycin for Asymptomatic Bacteriuria in Kidney Transplant Recipients: Results from a Spanish Multicenter Cohort

Published:2021-04-19 Issue:5 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ruiz-Ruigómez María¹,Fernández-Ruiz Mario¹,Silva José Tiago¹,Vidal Elisa²,Origüen Julia³^ORCID,Calvo‐Cano Antonia⁴,Luna‐Huerta Enrique⁵,Merino Esperanza⁶,Hernández Domingo⁷,Jironda‐Gallegos Cristina⁷,Escudero-Sánchez Rosa⁸,Gioia Francesca⁸,Moreno Antonio⁹,Roca Cristina⁹,Cordero Elisa⁹¹⁰,Janeiro Darío¹¹,Sánchez‐Sobrino Beatriz¹¹,Montero María Milagro¹²,Redondo Dolores¹³,Candel Francisco Javier¹⁴^ORCID,Pérez‐Flores Isabel¹⁵,Armiñanzas Carlos¹⁶,González-Rico Claudia¹⁶,Fariñas María Carmen¹⁶,Rodrigo Emilio¹⁷,Loeches Belén¹⁸,López‐Oliva María O.¹⁹,Montejo Miguel²⁰,Lauzurica Ricardo²¹,Horcajada Juan Pablo¹²,Pascual Julio¹³,Andrés Amado²²²³,Aguado José María¹²³,López-Medrano Francisco¹²³^ORCID

Affiliation:

1. Unit of Infectious Diseases, University Hospital 12 de Octubre, Instituto de Investigación Biomédica Hospital 12 de Octubre (imas12), Madrid, Spain

2. Unit of Infectious Diseases, University Hospital Reina Sofía, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba, Córdoba, Spain

3. Department of Emergency Medicine, University Hospital 12 de Octubre, Instituto de Investigación Biomédica Hospital 12 de Octubre (imas12), Madrid, Spain

4. Department of Infectious Diseases, University Hospital of Badajoz, Badajoz, Spain

5. Department of Nephrology, University Hospital of Badajoz, Badajoz, Spain

6. Unit of Infectious Diseases, General University Hospital of Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain

7. Department of Nephrology, Regional University Hospital Carlos Haya, Instituto de Investigación Biomédica de Málaga (IBIMA), Red de Investigación Renal (REDinREN)-RD16/0009/0006, Universidad de Málaga, Málaga, Spain

8. Department of Infectious Diseases, University Hospital Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain

9. Clinical Unit of Infectious Diseases, Microbiology, and Preventive Medicine, Infectious Diseases Research Group, Institute of Biomedicine of Seville (IBiS), University of Seville/CSIC/University Hospital Virgen del Rocío, Seville, Spain

10. Department of Medicine, University of Seville, Seville, Spain

11. Department of Nephrology, University Hospital Puerta de Hierro‐Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro Segovia de Arana, Majadahonda, Spain

12. Department of Infectious Diseases, Hospital del Mar, Instituto Hospital del Mar de Investigaciones Médicas (IMIM), Barcelona, Spain

13. Department of Nephrology, Hospital del Mar, Instituto Hospital del Mar de Investigaciones Médicas (IMIM), Barcelona, Spain

14. Department of Clinical Microbiology and Infectious Diseases, Hospital Clínico Universitario San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Transplant Coordination Unit, School of Medicine, Universidad Complutense, Madrid, Spain

15. Department of Nephrology, Hospital Clínico Universitario San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), School of Medicine, Universidad Complutense, Madrid, Spain

16. Department of Infectious Diseases, University Hospital Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), University of Cantabria, Santander, Spain

17. Department of Nephrology, University Hospital Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), University of Cantabria, Santander, Spain

18. Department of Microbiology, University Hospital La Paz, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Madrid, Spain

19. Department of Nephrology, University Hospital La Paz, Instituto de Investigación Hospital Universitario La Paz (IdiPAZ), Madrid, Spain

20. Unit of Infectious Diseases, University Hospital of Cruces, Universidad del País Vasco, Barakaldo, Spain

21. Department of Nephrology, University Hospital Germans Trias i Pujol, Badalona, Spain

22. Department of Nephrology, University Hospital 12 de Octubre, Instituto de Investigación Biomédica Hospital 12 de Octubre (imas12), Madrid, Spain

23. Department of Medicine, School of Medicine, Universidad Complutense, Madrid, Spain

Abstract

Current guidelines recommend against systematic screening for or treating asymptomatic bacteriuria (AB) among kidney transplant (KT) recipients, although the evidence regarding episodes occurring early after transplantation or in the presence of anatomical abnormalities is inconclusive. Oral fosfomycin may constitute a good option for the treatment of posttransplant AB, particularly due to the emergence of multidrug-resistant (MDR) uropathogens.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02267-20

Reference31 articles.

1. Systematic screening and treatment of asymptomatic bacteriuria in renal transplant recipients

2. Screening for asymptomatic bacteruria at one month after adult kidney transplantation: Clinical factors and implications

3. Should Asymptomatic Bacteriuria Be Systematically Treated in Kidney Transplant Recipients? Results From a Randomized Controlled Trial

4. Antibiotic Treatment Versus No Treatment for Asymptomatic Bacteriuria in Kidney Transplant Recipients: A Multicenter Randomized Trial

5. Antibiotics versus no therapy in kidney transplant recipients with asymptomatic bacteriuria (BiRT): a pragmatic, multicentre, randomized, controlled trial

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