Identification of the Herboxidiene Biosynthetic Gene Cluster in Streptomyces chromofuscus ATCC 49982-Reference-Cited by-同舟云学术

Identification of the Herboxidiene Biosynthetic Gene Cluster in Streptomyces chromofuscus ATCC 49982

Published:2012-03-15 Issue:6 Volume:78 Page:2034-2038
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Shao Lei¹,Zi Jiachen¹,Zeng Jia¹,Zhan Jixun¹

Affiliation:

1. Department of Biological Engineering, Utah State University, Logan, Utah, USA

Abstract

ABSTRACT The 53-kb biosynthetic gene cluster for the novel anticholesterol natural product herboxidiene was identified in Streptomyces chromofuscus ATCC 49982 by genome sequencing and gene inactivation. In addition to herboxidiene, a biosynthetic intermediate, 18-deoxy-herboxidiene, was also isolated from the fermentation broth of S. chromofuscus ATCC 49982 as a minor metabolite.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.06904-11

Reference27 articles.

1. Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway;Akey DL;Structure,2010

2. The RAST Server: Rapid Annotations using Subsystems Technology

3. Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp;Bierman M;Gene,1992

4. A chain initiation factor common to both modular and aromatic polyketide synthases;Bisang C;Nature,1999

5. A synthesis of herboxidiene;Blakemore PR;J. Chem. Soc. Perkin 1,1999

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