Age-related loss of Lyt-1,2 cells in C58 mice results in susceptibility to lactic dehydrogenase virus-induced polioencephalomyelitis

Author:

Bentley D M,Watson S R,Morris R E

Abstract

C58 mice (aged greater than or equal to 5 months) are susceptible to age-dependent polioencephalomyelitis, a paralytic central nervous system disease induced by lactic dehydrogenase virus. Susceptibility results from the loss of protective T cells. Data are presented showing a positive correlation between the age-related loss of Lyt-1,2 cells and the development of susceptibility to neuroparalytic lactic dehydrogenase virus infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference10 articles.

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3. Pathogenic mechanisms in immune polioencephalomyelitis: quantitative evaluation of protective and pathogenic effects of Iymphoid cells;Duffey P. S.;J. Immunol.,1976

4. Pathogenic mechanisms in immune polioencephalomyelitis: induction of disease in immunosuppressed mice;Duffey P. S.;J. Immunol.,1976

5. Helper and suppressor T cell factors;Germain R. N.;Springer Semin. Immunopathol.,1980

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