Impaired lung defenses against Staphylococcus aureus in mice with hereditary deficiency of the fifth component of complement-Reference-Cited by-同舟云学术

Impaired lung defenses against Staphylococcus aureus in mice with hereditary deficiency of the fifth component of complement

Published:1983-09 Issue:3 Volume:41 Page:1071-1076
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Cerquetti M C,Sordelli D O,Ortegon R A,Bellanti J A

Abstract

Mice of the C5-deficient DBA/2J and B10.D2/oSnJ inbred strains were aerosolized with Staphylococcus aureus, and the pulmonary clearance of bacteria was determined 4 h later. Both C5-deficient strains had a significantly decreased lung clearance of S. aureus compared with their genetically closest C5-sufficient relatives, DBA/1J and B10.D2/nSnJ strains, respectively. Serum hemolytic activity and pulmonary clearance of S. aureus were also investigated in F1 and F2 progenies (DBA/1J X DBA/2J and DBA/2J X B10.D2/oSnJ). Serum hemolytic activity was present in all F1 (DBA/1J X DBA/2J) mice, and their pulmonary clearance of S. aureus was no different from that of the C5-sufficient parents (DBA/1J). The absence of serum hemolytic activity (absence of C5) in all mice from F1 and F2 (DBA/2J X B10.D2/oSnJ) and 20% of the F2 (DBA/1J X DBA/2J) was related to a decreased lung clearance of S. aureus. These results are consistent with an autosomal recessive pattern of heredity for the murine abnormality in pulmonary clearance of S. aureus.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.41.3.1071-1076.1983

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