During the Early Stages of Staphylococcus aureus Biofilm Formation, Induced Neutrophil Extracellular Traps Are Degraded by Autologous Thermonuclease-Reference-Cited by-同舟云学术

During the Early Stages of Staphylococcus aureus Biofilm Formation, Induced Neutrophil Extracellular Traps Are Degraded by Autologous Thermonuclease

Published:2019-12 Issue:12 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Sultan Andi R.¹²,Hoppenbrouwers Tamara³⁴,Lemmens-den Toom Nicole A.¹,Snijders Susan V.¹,van Neck Johan W.⁴,Verbon Annelies¹,de Maat Moniek P. M.³,van Wamel Willem J. B.¹

Affiliation:

1. Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands

2. Department of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

3. Department of Hematology, Erasmus MC, Rotterdam, The Netherlands

4. Department of Plastic and Reconstructive Surgery, Erasmus MC, Rotterdam, The Netherlands

Abstract

Staphylococcus aureus extracellular DNA (eDNA) plays a crucial role in the structural stability of biofilms during bacterial colonization; on the contrary, host immune responses can be induced by bacterial eDNA. Previously, we observed production of S. aureus thermonuclease during the early stages of biofilm formation in a mammalian cell culture medium.

Funder

Ministry of Education and Culture | Direktorat Jenderal Pendidikan Tinggi

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00605-19

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