Affiliation:
1. Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, United Kingdom
2. Servicio de Microbiología-Unidad de Investigación, Complejo Hospitalario Universitario A Coruña-INIBIC, La Coruña, Spain
Abstract
ABSTRACT
Expression of
ampC
,
oprD
,
mexA
,
mexC
,
mexE
, and
mexX
was studied in 25
Pseudomonas aeruginosa
isolates from cystic fibrosis patients, including 14 isolates of the Liverpool epidemic strain. Overexpressed
mexA
or
ampC
and reduced
oprD
were associated with β-lactam resistance. A specific combination of
mexR
,
nalC
, and
nalD
mutations occurred in 11 Liverpool strain isolates, including 7 with upregulated
mexA
.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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