MTN-033: a Phase 1 Study Comparing Applicator versus “as Lubricant” Delivery of Rectal Dapivirine Gel-Reference-Cited by-同舟云学术

MTN-033: a Phase 1 Study Comparing Applicator versus “as Lubricant” Delivery of Rectal Dapivirine Gel

Published:2022-11-15 Issue:11 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ho Ken¹^ORCID,Dominguez-Islas Clara²,Szydlo Daniel²,Edick Stacey¹,Macagna Nicole³,Riddler Sharon A.¹,Brand Rhonda M.¹⁴,Jacobson Cindy E.⁴,Kramzer Lindsay⁴,Kunjara Na Ayudhya Ratiya P.⁵,Piper Jeanna⁶,Marzinke Mark A.⁷^ORCID,Bauermeister Jose⁸,Nuttall Jeremy⁹,Hillier Sharon L.¹⁴,Hendrix Craig W.⁷

Affiliation:

1. University of Pittsburgh, Pittsburgh, Pennsylvania, USA

2. Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, Washington, USA

3. FHI 360, Durham, North Carolina, USA

4. Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA

5. University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

6. Division of AIDS, NIAID, NIH, Bethesda, Maryland, USA

7. Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

8. University of Pennsylvania, Philadelphia, Pennsylvania, USA

9. International Partnership for Microbicides, Silver Spring, Maryland, USA

Abstract

Data to inform behaviorally congruent delivery of rectal microbicides as lubricants are scant. Dapivirine (DPV) is a nonnucleoside reverse transcriptase inhibitor which has been demonstrated to be well-tolerated and efficacious in multiple clinical trials when used in a vaginal ring formulation.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00816-22

Reference24 articles.

1. Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women

2. Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men

3. On-Demand Preexposure Prophylaxis in Men at High Risk for HIV-1 Infection

4. Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women

5. Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial

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