Poly(A)-Binding Protein-Interacting Protein 1 Binds to Eukaryotic Translation Initiation Factor 3 To Stimulate Translation-Reference-Cited by-同舟云学术

Poly(A)-Binding Protein-Interacting Protein 1 Binds to Eukaryotic Translation Initiation Factor 3 To Stimulate Translation

Published:2008-11 Issue:21 Volume:28 Page:6658-6667
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Martineau Yvan¹,Derry Mélanie C.¹,Wang Xiaoshan¹,Yanagiya Akiko¹,Berlanga Juan José²,Shyu Ann-Bin³,Imataka Hiroaki⁴,Gehring Kalle¹,Sonenberg Nahum¹⁵

Affiliation:

1. Department of Biochemistry

2. Centro de Biologìa Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autõnoma de Madrid, Cantoblanco 28049 Madrid, Spain

3. Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, Texas 77030

4. RIKEN Systems and Structural Biology Center, Tsurumi-ku, Yokohama, Japan

5. McGill Cancer Centre, McGill University, 3655 Promenade Sir William Osler, Montreal, Québec, Canada H3G 1Y6

Abstract

ABSTRACT Poly(A)-binding protein (PABP) stimulates translation initiation by binding simultaneously to the mRNA poly(A) tail and eukaryotic translation initiation factor 4G (eIF4G). PABP activity is regulated by PABP-interacting (Paip) proteins. Paip1 binds PABP and stimulates translation by an unknown mechanism. Here, we describe the interaction between Paip1 and eIF3, which is direct, RNA independent, and mediated via the eIF3g (p44) subunit. Stimulation of translation by Paip1 in vivo was decreased upon deletion of the N-terminal sequence containing the eIF3-binding domain and upon silencing of PABP or several eIF3 subunits. We also show the formation of ternary complexes composed of Paip1-PABP-eIF4G and Paip1-eIF3-eIF4G. Taken together, these data demonstrate that the eIF3-Paip1 interaction promotes translation. We propose that eIF3-Paip1 stabilizes the interaction between PABP and eIF4G, which brings about the circularization of the mRNA.

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00738-08

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