Affiliation:
1. Department of Microbiology and Immunology, Cornell University Medical College, New York, New York
Abstract
O'Leary, William
M. (Cornell University Medical College, New York, N.Y.). S-adenosylmethionine in the biosynthesis of bacterial fatty acids. J. Bacteriol.
84:
967–972. 1962.—The fatty-acid contents of a wild strain of
Aerobacter aerogenes
and of three auxotrophic mutants were determined by the use of gas-liquid chromatography. All strains studied exhibited essentially identical fatty-acid spectra. This organism was shown to contain large amounts of a C
17
cyclopropane fatty acid, and it is suggested that it may be a convenient natural source of this compound. By use of the auxotrophic mutants which have varying requirements for exogenous sources of methionine and S-adenosylmethionine, it was shown by means of radioisotope tracer techniques that S-adenosylmethionine functions in this organism as a donor of a one-carbon unit that is used to form the ring structure in the biosynthesis of cyclopropane fatty acids.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference19 articles.
1. Sur quelques applications de la chromatographie en phase gazeuse a 1'e'tude d'acides gras bacteriens. Ann. inst;SELINEAU J.;Pasteur,1961
2. The incorporation of (Me-14C)methionine into lactobacillic acid;CHALK K. J.;Biochim. et Biophys. Acta,1961
3. DAUCHY S. AND J. ASSELINEAU. 1960. Sur les acides gras des lipides de Escherichia coli. Existence d'un acide C17H3202 contenant un cycle propanique. Compt. rend. 250:2635-2637.
4. Mutants of Escherichia coli requiring methionine or vitamin B12;DAV;J. Bacteriol.,1950
5. On the origin of unsaturated fatty acids in clostridia;GOLDFINE H.;J. Biol. Chem.,1961
Cited by
46 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献