A Natural History of Actinic Keratosis and Cutaneous Squamous Cell Carcinoma Microbiomes

Author:

Wood David L. A.1,Lachner Nancy1,Tan Jean-Marie2345,Tang Stephanie2345,Angel Nicola1,Laino Antonia2345,Linedale Richard45,Lê Cao Kim-Anh456,Morrison Mark45,Frazer Ian H.2345,Soyer H. Peter2345,Hugenholtz Philip145

Affiliation:

1. Australian Centre for Ecogenomics, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia

2. Dermatology Research Centre, The University of Queensland, Brisbane, Queensland, Australia

3. Dermatology Department, Princess Alexandra Hospital, Brisbane, Queensland, Australia

4. Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia

5. Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia

6. School of Mathematics and Statistics, Melbourne Integrative Genomics, The University of Melbourne, Victoria, Australia

Abstract

Actinic keratosis (AK) and cutaneous squamous cell carcinoma (SCC) are two of the most common dermatologic conditions in Western countries and cause substantial morbidity worldwide. The role of human papillomaviruses under these conditions has been well studied yet remains inconclusive. One PCR-based study has investigated bacteria in the etiology of these conditions; however, no study has investigated the microbiomes of AK and SCC more broadly. We longitudinally profiled the microbiomes of 112 AK lesions, profiled cross sections of 32 spontaneously arising SCC lesions, and compared these to matching nonlesional photodamaged control skin sites. We identified commonly occurring strains of Propionibacterium and Malassezia at higher relative abundances on nonlesional skin than in AK and SCC lesions, and strains of Staphylococcus aureus were relatively more abundant in lesional than nonlesional skin. These findings may aid in the prevention of SCC.

Funder

Department of Health | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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