Ancient Gene Capture and Recent Gene Loss Shape the Evolution of Orthopoxvirus-Host Interaction Genes-Reference-Cited by-同舟云学术

Ancient Gene Capture and Recent Gene Loss Shape the Evolution of Orthopoxvirus-Host Interaction Genes

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Senkevich Tatiana G.¹,Yutin Natalya²,Wolf Yuri I.²^ORCID,Koonin Eugene V.²^ORCID,Moss Bernard¹^ORCID

Affiliation:

1. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Instutes of Health, Bethesda, Maryland, USA

2. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA

Abstract

Orthopoxviruses (ORPV) include smallpox (variola) virus, one of the most devastating human pathogens, and vaccinia virus, comprising the vaccine used for smallpox eradication. Among roughly 200 ORPV genes, about half are essential for genome replication and expression as well as virion morphogenesis, whereas the remaining half consists of accessory genes counteracting the host immune response.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

HHS | NIH | U.S. National Library of Medicine

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01495-21

Reference102 articles.

1. Moss D, Smith GL. Poxviridae: The Viruses and Their Replication. In: Fields Virology. Vol 2, 7 ed: LWW; 2021.

2. Fenner F, Wittek R, Dumbell KR. 1988. The Otrhopxviruses. Academic Press, Boca Raton, FL.