Affiliation:
1. Department of Genetics, University of Washington, Seattle, Washington 98105
Abstract
Alkaline phosphatase is induced in excess phosphate media by starvation either for pyrimidines or for guanine. Induction is observed both during starvation, after a lag period, and following a period of starvation. Induction is not caused by a lowering of the internal orthophosphate pool, but is linked to alterations in the levels of the nucleotide pools. Experiments with purine-requiring mutants suggest that phosphatase is induced in wild-type strains by an adenine nucleotide. Mutations in the
phoR
gene can produce differential responses to the different starvation regimes.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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