Pneumococcal Extracellular Vesicles Modulate Host Immunity-Reference-Cited by-同舟云学术

Pneumococcal Extracellular Vesicles Modulate Host Immunity

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Yerneni Saigopalakrishna S.¹,Werner Sarah²,Azambuja Juliana H.³⁴,Ludwig Nils³⁴⁵,Eutsey Rory²,Aggarwal Surya D.²^ORCID,Lucas Peter C.³⁴,Bailey Nathanael⁴,Whiteside Theresa L.³⁴⁶,Campbell Phil G.¹⁷,Hiller N. Luisa²^ORCID

Affiliation:

1. Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA

2. Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA

3. UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

4. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

5. Department of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany

6. Departments of Immunology and Otolaryngology, Pittsburgh, Pennsylvania, USA

7. Engineering Research Accelerator, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA

Abstract

Our studies reveal that Streptococcus pneumoniae (pneumococcus) (pEVs) are internalized by macrophages, T cells, and epithelial cells. In vitro , pEVs induce NF-κB activation in a dosage-dependent manner and polarize human macrophages to an alternative (M2) phenotype. In addition, pEV pretreatment conditions macrophages to increase bacteria uptake and such macrophages may act as a reservoir for pneumococcal cells by increasing survival of the phagocytosed bacteria.

Funder

Shurl and Kay Curci Foundation

NSF Graduate Research Fellowship

Glen deVries Presidential Award

Leopoldina Fellowship

Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01657-21