Role of Premycofactocin Synthase in Growth, Microaerophilic Adaptation, and Metabolism of Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Role of Premycofactocin Synthase in Growth, Microaerophilic Adaptation, and Metabolism of Mycobacterium tuberculosis

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Krishnamoorthy Gopinath¹^ORCID,Kaiser Peggy¹,Constant Patricia²,Abu Abed Ulrike³,Schmid Monika⁴,Frese Christian K.⁵^ORCID,Brinkmann Volker³,Daffé Mamadou²,Kaufmann Stefan H. E.¹⁶⁷

Affiliation:

1. Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany

2. Département Tuberculose & Biologie des Infections, Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, Toulouse, France

3. Core Facility Microscopy, Max Planck Institute for Infection Biology, Berlin, Germany

4. Core Facility Proteomics, Max Planck Institute for Infection Biology, Berlin, Germany

5. Max-Planck-Unit for the Science of Pathogens, Berlin, Germany

6. Hagler Institute for Advanced Study at Texas A&M University, College Station, Texas, USA

7. Max Planck Institute for Biophysical Chemistry, Göttingen, Germany

Abstract

Characterization of proteins with unknown functions is a critical research priority as the intracellular growth and metabolic state of Mycobacterium tuberculosis , the causative agent of tuberculosis, remain poorly understood. Mycofactocin is a peptide-derived redox cofactor present in almost all mycobacterial species; however, its functional relevance in M. tuberculosis pathogenesis and host survival has never been studied experimentally.

Funder

Max-Planck-Gesellschaft

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01665-21

Reference67 articles.

1. WHO. 2020. Global tuberculosis report 2020. WHO Geneva Switzerland. https://www.who.int/publications/i/item/9789240013131.

2. Mycobacterium tuberculosis: success through dormancy

3. Mycobacterium tuberculosis Metabolism