Impaired Succinate Oxidation Prevents Growth and Influences Drug Susceptibility in Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Impaired Succinate Oxidation Prevents Growth and Influences Drug Susceptibility in Mycobacterium tuberculosis

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Adolph Cara¹²^ORCID,McNeil Matthew B.¹²,Cook Gregory M.¹²^ORCID

Affiliation:

1. Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand

2. Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand

Abstract

New drugs are urgently required to combat the tuberculosis epidemic that claims 1.5 million lives annually. Inhibitors of mycobacterial energy metabolism have shown significant promise clinically; however, further advancing this nascent target space requires a more fundamental understanding of the respiratory enzymes and pathways used by Mycobacterium tuberculosis .

Funder

Manatu Hauora | Health Research Council of New Zealand

Maurice Wilkins Centre

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01672-22

Reference99 articles.

1. World Health Organization. 2021. Global tuberculosis report. World Health Organization, Geneva, Switzerland.

2. World Health Organization. 2010. Guidelines for the treatment of tuberculosis, 4th ed. World Health Organization, Geneva, Switzerland.