Extracellular Loops of the Treponema pallidum FadL Orthologs TP0856 and TP0858 Elicit IgG Antibodies and IgG<sup>+</sup>-Specific B-Cells in the Rabbit Model of Experimental Syphilis-Reference-Cited by-同舟云学术

Extracellular Loops of the Treponema pallidum FadL Orthologs TP0856 and TP0858 Elicit IgG Antibodies and IgG⁺-Specific B-Cells in the Rabbit Model of Experimental Syphilis

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Delgado Kristina N.¹,Montezuma-Rusca Jairo M.¹²³,Orbe Isabel C.³,Caimano Melissa J.¹³⁴,La Vake Carson J.³,Luthra Amit¹⁴,Hennelly Christopher M.⁵,Nindo Fredrick N.⁵,Meyer Jacob W.⁶,Jones Letitia D.⁶,Parr Jonathan B.⁵,Salazar Juan C.³⁷⁸,Moody M. Anthony⁶⁹¹⁰,Radolf Justin D.¹³⁴⁸¹¹,Hawley Kelly L.¹³⁷^ORCID

Affiliation:

1. Department of Medicine, UConn Health, Farmington, Connecticut, USA

2. Division of Infectious Diseases, UConn Health, Farmington, Connecticut, USA

3. Department of Pediatrics, UConn Health, Farmington, Connecticut, USA

4. Department of Molecular Biology and Biophysics, UConn Health, Farmington, Connecticut, USA

5. Division of Infectious Diseases, Department of Medicine, and Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA

6. Duke Human Vaccine Institute, Durham, North Carolina, USA

7. Division of Infectious Diseases and Immunology, Connecticut Children’s, Hartford, Connecticut, USA

8. Department of Immunology, UConn Health, Farmington, Connecticut, USA

9. Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA

10. Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA

11. Department of Genetics and Genome Sciences, UConn Health, Farmington, Connecticut, USA

Abstract

Recent identification and structural modeling ofTreponema pallidum’s (Tp) repertoire of outer membrane proteins (OMPs) represent a critical breakthrough in the decades long quest for a syphilis vaccine. However, little is known about the antigenic nature of these β-barrel-forming OMPs and, more specifically, their surface exposed regions, the extracellular loops (ECLs).

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Connecticut Children's Medical Center

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01639-22

Reference89 articles.

1. The global roadmap for advancing development of vaccines against sexually transmitted infections: Update and next steps

2. Vaccine development for syphilis