Signaling through Syk or CARD9 Mediates Species-Specific Anti- Candida Protection in Bone Marrow Chimeric Mice-Reference-Cited by-同舟云学术

Signaling through Syk or CARD9 Mediates Species-Specific Anti- Candida Protection in Bone Marrow Chimeric Mice

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Zajta Erik¹,Csonka Katalin¹,Tóth Adél¹,Tiszlavicz Laszló²,Németh Tamás³⁴,Orosz Anita³,Novák Ádám¹,Csikós Máté¹,Vágvölgyi Csaba¹,Mócsai Attila³,Gácser Attila¹⁵

Affiliation:

1. HCEMM-USZ Fungal Pathogens Research Group, Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary

2. Department of Pathology, University of Szeged, Szeged, Hungary

3. Department of Physiology, Semmelweis University School of Medicine, Budapest, Hungary

4. Department of Rheumatology and Clinical Immunology, Semmelweis University, Budapest, Hungary

5. MTA-SZTE “Lendület” Mycobiome Research Group, University of Szeged, Szeged, Hungary

Abstract

While C. albicans remains the most clinically significant Candida species, C. parapsilosis is an emerging pathogen with increased affinity to neonates. Syk/CARD9 signaling is crucial in immunity to C. albicans , but its role in in vivo responses to other pathogenic Candida species is largely unexplored.

Funder

National Excellence Programme

Nemzeti Kutatási, Fejlesztési és Innovaciós Alap

Magyarország Kormánya

Magyar Tudományos Akadémia

Hungarian Ministry of National Economy

European Commission Horizon 2020 research and innovation program

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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