Superantigen Expression Is Driven by Both Mouse Mammary Tumor Virus Long Terminal Repeat-Associated Promoters in Transgenic Mice-Reference-Cited by-同舟云学术

Superantigen Expression Is Driven by Both Mouse Mammary Tumor Virus Long Terminal Repeat-Associated Promoters in Transgenic Mice

Published:2000-03-15 Issue:6 Volume:74 Page:2900-2902
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Salmons Brian¹,Miethke Thomas²,Wintersperger Stefan³,Müller Mathias⁴,Brem Gottfried⁴,Günzburg Walter H.³⁵

Affiliation:

1. Bavarian Nordic, D-82152 Martinsried,1

2. Institute for Microbiology and Hygiene, Technical University, D-80539 Munich,2 and

3. Institute of Molecular Virology, GSF-Neuherberg, D-85758 Oberschleissheim,3 Germany, and

4. Institute of Animal Breeding and Genetics4 and

5. Institute of Virology,5 University of Veterinary Sciences, A-1210 Vienna, Austria

Abstract

ABSTRACT In addition to the usual retroviral promoter, the mouse mammary tumor virus (MMTV) long terminal repeat carries a second promoter located in the U3 region. Here we show that both of these promoters are independently able to give rise to superantigen activity in transgenic mice. The ability of multiple MMTV promoters to drive superantigen expression underscores its importance in the virus life cycle.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.6.2900-2902.2000

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