In vitro activity of N-formimidoyl thienamycin and other beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus

Author:

Thompson R L,Fisher K A,Wenzel R P

Abstract

Of 43 isolates of methicillin-resistant Staphylococcus aureus, 90% were inhibited by 8 micrograms or less of N-formimidoyl thienamycin per ml by the agar-dilution technique. Cefamandole, cefotaxime, cefoperazone, moxalactam, and cefsulodin showed relatively poor activity. Vancomycin was the most active compound by weight, inhibiting 93% of strains at 1 microgram/ml.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference16 articles.

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4. Centers for Disease Control. 1981. Methicillin-resistant Staphylococcus aureus-United States. Morbid. Mortal. Weekly Rep. 30-.140-147.

5. Antibiotic sensitivity testing. Report of an international collaborative study;ErIcson J. M.;Acta Pathol. Microbiol. Scand. Sect. B 217: (Suppl.)1-90.,1971

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